Pesquisa | BVS Violência e Saúde

1.

A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization.

Singh, Tulika; Hwang, Kwan-Ki; Miller, Andrew S; Jones, Rebecca L; Lopez, Cesar A; Dulson, Sarah J; Giuberti, Camila; Gladden, Morgan A; Miller, Itzayana; Webster, Helen S; Eudailey, Joshua A; Luo, Kan; Von Holle, Tarra; Edwards, Robert J; Valencia, Sarah; Burgomaster, Katherine E; Zhang, Summer; Mangold, Jesse F; Tu, Joshua J; Dennis, Maria; Alam, S Munir; Premkumar, Lakshmanane; Dietze, Reynaldo; Pierson, Theodore C; Ooi, Eng Eong; Lazear, Helen M; Kuhn, Richard J; Permar, Sallie R; Bonsignori, Mattia.

Cell ; 185(25): 4826-4840.e17, 2022 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-36402135

2.

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope.

Robinson, Luke N; Tharakaraman, Kannan; Rowley, Kirk J; Costa, Vivian V; Chan, Kuan Rong; Wong, Yee Hwa; Ong, Li Ching; Tan, Hwee Cheng; Koch, Tyree; Cain, David; Kirloskar, Rama; Viswanathan, Karthik; Liew, Chong Wai; Tissire, Hamid; Ramakrishnan, Boopathy; Myette, James R; Babcock, Gregory J; Sasisekharan, V; Alonso, Sylvie; Chen, Jianzhu; Lescar, Julien; Shriver, Zachary; Ooi, Eng Eong; Sasisekharan, Ram.

Cell ; 162(3): 493-504, 2015 Jul 30.

Artigo em Inglês | MEDLINE | ID: mdl-26189681

3.

A potential silver lining of delaying the second dose.

Martinez, David R; Ooi, Eng Eong.

Nat Immunol ; 23(3): 349-351, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35190721

4.

Minding the "T"s beyond the "B"s: Shaping vaccines for future pandemics.

Kalimuddin, Shirin; Ooi, Eng Eong.

PLoS Biol ; 21(11): e3002351, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37934720

5.

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.

Le Bert, Nina; Tan, Anthony T; Kunasegaran, Kamini; Tham, Christine Y L; Hafezi, Morteza; Chia, Adeline; Chng, Melissa Hui Yen; Lin, Meiyin; Tan, Nicole; Linster, Martin; Chia, Wan Ni; Chen, Mark I-Cheng; Wang, Lin-Fa; Ooi, Eng Eong; Kalimuddin, Shirin; Tambyah, Paul Anantharajah; Low, Jenny Guek-Hong; Tan, Yee-Joo; Bertoletti, Antonio.

Nature ; 584(7821): 457-462, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32668444

6.

Adverse effects following anti-COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes.

Syenina, Ayesa; Gan, Esther S; Toh, Justin Z N; de Alwis, Ruklanthi; Lin, Lowell Z; Tham, Christine Y L; Yee, Jia Xin; Leong, Yan Shan; Sam, Huizhen; Cheong, Charlene; Teh, Yii Ean; Wee, Ian L E; Ng, Dorothy H L; Chan, Kuan Rong; Sim, Jean X Y; Kalimuddin, Shirin; Ong, Eugenia Z; Low, Jenny G; Ooi, Eng Eong.

PLoS Biol ; 20(5): e3001643, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35639676

7.

Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells.

Victorio, Carla Bianca Luena; Novera, Wisna; Ganasarajah, Arun; Ong, Joanne; Thomas, Melisyaa; Wu, Jonas; Toh, Hilary Si Yin; Sun, Alfred Xuyang; Ooi, Eng Eong; Chacko, Ann-Marie.

J Transl Med ; 22(1): 126, 2024 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-38308299

8.

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection.

Yousefi, Meisam; Lee, Wai Suet; Yan, Biaoguo; Cui, Liang; Yong, Cythia Lingli; Yap, Xin; Tay, Kwan Sing Leona; Qiao, Wenjie; Tan, Dewei; Nurazmi, Nur Insyirah; Linster, Martin; Smith, Gavin J D; Lee, Yie Hou; Carette, Jan E; Ooi, Eng Eong; Chan, Kuan Rong; Ooi, Yaw Shin.

PLoS Pathog ; 18(8): e1010763, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35939522

9.

Phase 1 Trial of a Therapeutic Anti-Yellow Fever Virus Human Antibody.

Low, Jenny G; Ng, Justin H J; Ong, Eugenia Z; Kalimuddin, Shirin; Wijaya, Limin; Chan, Yvonne F Z; Ng, Dorothy H L; Tan, Hwee-Cheng; Baglody, Anjali; Chionh, Yok-Hian; Lee, Debbie C P; Budigi, Yadunanda; Sasisekharan, Ram; Ooi, Eng-Eong.

N Engl J Med ; 383(5): 452-459, 2020 07 30.

Artigo em Inglês | MEDLINE | ID: mdl-32726531

10.

Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection.

Bifani, Amanda M; Tan, Hwee Cheng; Choy, Milly M; Ooi, Eng Eong.

J Virol ; 96(3): e0173721, 2022 02 09.

Artigo em Inglês | MEDLINE | ID: mdl-34851147

11.

Positive epistasis between viral polymerase and the 3' untranslated region of its genome reveals the epidemiologic fitness of dengue virus.

Syenina, Ayesa; Vijaykrishna, Dhanasekaran; Gan, Esther Shuyi; Tan, Hwee Cheng; Choy, Milly M; Siriphanitchakorn, Tanamas; Cheng, Colin; Vasudevan, Subhash G; Ooi, Eng Eong.

Proc Natl Acad Sci U S A ; 117(20): 11038-11047, 2020 05 19.

Artigo em Inglês | MEDLINE | ID: mdl-32366663

12.

Hyperinflammatory Syndrome, Natural Killer Cell Function, and Genetic Polymorphisms in the Pathogenesis of Severe Dengue.

Vuong, Nguyen Lam; Cheung, Ka Wai; Periaswamy, Balamurugan; Vi, Tran Thuy; Duyen, Huynh Thi Le; Leong, Yan Shan; Binte Hamis, Zayanah Noor; Gregorova, Michaela; Ooi, Eng Eong; Sessions, October; Rivino, Laura; Yacoub, Sophie.

J Infect Dis ; 226(8): 1338-1347, 2022 10 17.

Artigo em Inglês | MEDLINE | ID: mdl-35267010

13.

Immune Immunomodulation in Coronavirus Disease 2019 (COVID-19): Strategic Considerations for Personalized Therapeutic Intervention.

Hall, Mark W; Joshi, Ila; Leal, Luis; Ooi, Eng Eong.

Clin Infect Dis ; 74(1): 144-148, 2022 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-32604407

14.

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.

de Alwis, Ruklanthi; Gan, Esther S; Chen, Shiwei; Leong, Yan Shan; Tan, Hwee Cheng; Zhang, Summer L; Yau, Clement; Low, Jenny G H; Kalimuddin, Shirin; Matsuda, Daiki; Allen, Elizabeth C; Hartman, Paula; Park, Kyoung-Joo Jenny; Alayyoubi, Maher; Bhaskaran, Hari; Dukanovic, Adrian; Bao, Yanjie; Clemente, Brenda; Vega, Jerel; Roberts, Scott; Gonzalez, Jose A; Sablad, Marciano; Yelin, Rodrigo; Taylor, Wendy; Tachikawa, Kiyoshi; Parker, Suezanne; Karmali, Priya; Davis, Jared; Sullivan, Brian M; Sullivan, Sean M; Hughes, Steve G; Chivukula, Pad; Ooi, Eng Eong.

Mol Ther ; 29(6): 1970-1983, 2021 06 02.

Artigo em Inglês | MEDLINE | ID: mdl-33823303

15.

Hypoxia enhances antibody-dependent dengue virus infection.

Gan, Esther Shuyi; Cheong, Wei Fun; Chan, Kuan Rong; Ong, Eugenia Ziying; Chai, Xiaoran; Tan, Hwee Cheng; Ghosh, Sujoy; Wenk, Markus R; Ooi, Eng Eong.

EMBO J ; 36(10): 1348-1363, 2017 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-28320741

16.

Revisiting dengue virus-mosquito interactions: molecular insights into viral fitness.

Siriphanitchakorn, Tanamas; Kini, R Manjunatha; Ooi, Eng Eong; Choy, Milly M.

J Gen Virol ; 102(11)2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34845981

17.

Amplified parallel antigen rapid test for point-of-care salivary detection of SARS-CoV-2 with improved sensitivity.

Tng, Danny Jian Hang; Yin, Bryan Chu Yang; Cao, Jing; Ko, Kwan Ki Karrie; Goh, Kenneth Choon Meng; Chua, Delia Xue Wen; Zhang, Yong; Chua, Melvin Lee Kiang; Low, Jenny Guek Hong; Ooi, Eng Eong; Soo, Khee Chee.

Mikrochim Acta ; 189(1): 14, 2021 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-34870771

18.

Dengue.

Wilder-Smith, Annelies; Ooi, Eng-Eong; Horstick, Olaf; Wills, Bridget.

Lancet ; 393(10169): 350-363, 2019 01 26.

Artigo em Inglês | MEDLINE | ID: mdl-30696575

19.

Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.

Liao, Kuo-Chieh; Chuo, Vanessa; Ng, Wy Ching; Neo, Suat Peng; Pompon, Julien; Gunaratne, Jayantha; Ooi, Eng Eong; Garcia-Blanco, Mariano A.

RNA ; 24(6): 803-814, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29572260

20.

Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway.

Ye, Weijian; Chew, Marvin; Hou, Jue; Lai, Fritz; Leopold, Stije J; Loo, Hooi Linn; Ghose, Aniruddha; Dutta, Ashok K; Chen, Qingfeng; Ooi, Eng Eong; White, Nicholas J; Dondorp, Arjen M; Preiser, Peter; Chen, Jianzhu.

PLoS Pathog ; 14(10): e1007298, 2018 10.

Artigo em Inglês | MEDLINE | ID: mdl-30286211

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